Do Female Dogs Have Estrogen? Understanding Your Dog’s Hormonal Health

October 2, 2025 |

Estrogen — a type of hormone — is naturally produced in female dogs. It is responsible for normal sexual behavior and development, and the customary biological function of the female reproductive tract. Overproduction of estrogen can result in what is known as estrogen toxicity (hyperestrogenism). This can happen without any outside interference or it can occur when estrogens are being introduced artificially.

Estrogens sometimes cause abnormal (cystic) cells to line the uterus and this permits the invasion of bacteria from the vagina. The cervix is open during “heat,” but if it is closed it can lead to a serious infection (pyometra). In addition, a concentration of estrogen can result in infertility, as well as an imbalance in the blood.

Recovery may take a while — up to several months — so be prepared to provide long-term care for your pet. Be vigilant in providing prescribed medications and aware of any changes in your pet. Blood tests (and sometimes bone-marrow biopsies) must be performed to evaluate your pets response to the therapy.

Do not give estrogen-containing compounds unless advised to by your veterinarian. Females will undergo tests to determine whether ovulation is occurring.

In addition, a male dog should not show signs of feminization once a testicular tumor has been removed.

Yes, female dogs absolutely have estrogen! This crucial hormone plays a major role in your furry friend’s reproductive health and overall wellbeing. As a pet parent, understanding how estrogen affects your dog can help you better care for her throughout her life stages

What Exactly Is Estrogen in Dogs?

Estrogen is a steroid hormone that’s primarily produced in your female dog’s ovaries. It’s one of the key sex hormones responsible for

  • Sexual development in female dogs
  • Controlling reproductive behavior
  • Regulating the heat cycle
  • Supporting pregnancy

While we often associate estrogen with female dogs, it’s important to note that both male and female dogs produce estrogen, though females typically have higher levels. In males, smaller amounts help maintain bone density and contribute to overall hormonal balance.

The Role of Estrogen in Your Dog’s Heat Cycle

The heat cycle (also called estrus cycle) in female dogs is heavily influenced by hormonal changes, with estrogen being one of the most important players Several hormones work together during this cycle

  1. Estrogen – Initiates the heat cycle and rises during the first stage
  2. Luteinizing Hormone (LH) – Surges to trigger ovulation
  3. Progesterone – Maintains pregnancy if fertilization occurs

During the first days of heat, your dog’s estrogen levels climb steadily. This rise in estrogen causes:

  • Swelling of the vulva
  • Creation of bloody vaginal discharge from the uterine lining
  • Lubrication of the uterus (essential for later implantation)

Estrogen typically reaches its maximum about two days before the beginning of the second phase of heat (the Estrus stage) and then decreases rapidly. This peak actually triggers a sudden surge in LH, which leads to ovulation.

Signs of Normal Estrogen Function

When your female dog’s estrogen levels are functioning normally, you’ll notice:

  • Regular heat cycles (typically every 6-7 months, though this varies by breed)
  • Normal development of secondary sex characteristics
  • Healthy reproductive function
  • Normal bone development
  • Balanced behavior

When Estrogen Goes Wrong: Hyperestrogenism

Just like any hormone, too much estrogen can cause problems. Hyperestrogenism (or estrogen toxicity) occurs when there’s an overproduction of estrogen in your dog’s body. This condition can affect both female and male dogs.

Causes of Elevated Estrogen in Female Dogs

Female dogs most commonly experience elevated estrogen due to:

  • Ovarian cysts
  • Ovarian tumors
  • Functional ovarian tissue remaining after spaying
  • Exposure to external estrogen sources (like certain medications)

Symptoms of Hyperestrogenism to Watch For

If your dog is experiencing estrogen overproduction, you might notice:

  • Lethargy
  • Pale gums
  • Blood in urine, stool and/or vomit
  • Fever
  • Recurring infections
  • Thinning hair or hair loss (especially symmetrical on the flanks and trunk)
  • Darkening of the skin (hyperpigmentation)
  • Prolonged heat cycles in females
  • Enlarged vulva and/or teats
  • Bleeding from the vulva
  • Increased attraction to male dogs
  • Infertility

Diagnosis of Estrogen Imbalances

If you suspect your dog might have an estrogen imbalance, your vet will likely conduct:

  • A thorough physical examination
  • Complete blood count to check red and white blood cell levels
  • Chemical blood profile
  • Urinalysis
  • Skin biopsy (if hair loss is present)
  • Lymph node biopsy
  • Bone marrow biopsy
  • X-rays or ultrasound of the abdomen
  • Examination of reproductive organs

Treatment Options for Estrogen Imbalances

Treatment will depend on the underlying cause and severity of the condition:

  1. Discontinue Hormone Supplementation: If the issue is caused by artificial hormone therapy, this will be stopped immediately.

  2. Stabilization: Your dog may need antibiotics or even blood transfusions in severe cases.

  3. Surgical Intervention: Often, spaying (for females) or neutering (for males) is recommended to stabilize hormone levels. This may include:

    • Removal of ovarian cysts or tumors
    • Complete removal of ovaries if necessary
    • Removal of testicular masses in males
  4. Medication: In some cases, medications may be prescribed to:

    • Increase blood cell production in bone marrow
    • Induce ovulation in cases of ovarian cysts

Recovery and Management

Recovery from estrogen imbalances can be a slow process. Your dog’s hormonal balance is delicate and may take months to return to normal. During this time:

  • Follow all vet instructions carefully
  • Administer medications as prescribed
  • Attend all follow-up appointments
  • Monitor surgical sites if your dog had surgery
  • Never give hormonal supplements without veterinary guidance

With proper treatment, most dogs recover fully, though it may take time.

Do Dogs Go Through Menopause?

An interesting fact: unlike humans, female dogs don’t experience menopause as they age! Their ovaries can continue to produce eggs throughout their lives, though they may cycle less frequently as they get older.

However, aging female dogs can experience hormonal changes that include decreased estrogen levels. This can lead to:

  • Urinary tract infections
  • Incontinence
  • Weight gain
  • Behavioral changes like increased aggression or restlessness

Many vets recommend spaying female dogs once they’re done breeding, especially as they approach 8 years of age, to prevent complications like pyometra (a potentially life-threatening uterine infection).

Hormones During Pregnancy

If your female dog becomes pregnant, hormones continue to play crucial roles:

  • Progesterone remains elevated to maintain the pregnancy
  • Estrogen rises to prepare the mammary glands for lactation

Regular veterinary care throughout pregnancy is essential to monitor hormonal health and ensure both mom and puppies remain healthy.

The Cost of Treating Estrogen-Related Conditions

Treatment for estrogen-related conditions can vary widely in cost. According to some veterinary sources, treating overproduction of estrogen can range from $500 to $6,000, with an average cost of around $2,500.

This wide range reflects the variety of potential treatments needed:

  • Diagnostic testing
  • Surgery
  • Medication
  • Follow-up care

Pet insurance can help offset these costs, so it’s worth considering if you have an intact female dog.

Protecting Your Dog’s Hormonal Health

Here are some ways to help maintain your dog’s hormonal health:

  • Schedule regular veterinary check-ups
  • Consider spaying if you don’t plan to breed your dog
  • Be aware of the signs of hormonal imbalance
  • Monitor changes in behavior, appetite, and appearance
  • Keep your dog at a healthy weight
  • Provide a balanced diet

When to Call the Vet

Contact your veterinarian immediately if you notice:

  • Unusual vaginal discharge or bleeding outside of normal heat cycles
  • Significant behavior changes
  • Hair loss
  • Lethargy or weakness
  • Signs of infection
  • Changes in urination habits

Estrogen is a vital hormone in your female dog’s body that affects everything from reproduction to bone health. While hormonal imbalances can occur, understanding the signs and seeking prompt veterinary care can help ensure your furry friend lives a long, healthy life.

Regular veterinary check-ups are the best way to monitor your dog’s hormonal health and catch any issues early. If you have questions about your dog’s reproductive health or hormonal balance, don’t hesitate to discuss them with your veterinarian.

We at [Your Blog Name] believe that understanding your pet’s body is key to providing the best possible care. After all, our furry friends can’t tell us when something’s wrong – it’s up to us to notice the signs and get them the help they need!

Have you noticed any changes in your female dog that might be hormone-related? Share your experiences in the comments below!

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FAQ

Does a female dog have estrogen?

Estrogen is the hormone that controls sexual development, behavior and reproduction in female dogs. However, estrogen is produced in both male and female dogs. Overproduction of estrogen can cause complications of the reproductive organs and even estrogen toxicity, known as hyperestrogenism. Protect yourself and your pet.

What does a male dog have instead of estrogen?

Instead of estrogen, testosterone is what a male dog has also like us humans. As a side note, estrogen is actually a group of hormones of which the most known is estradiol. The list of estrogen’s functions is quite long; you can look it up at Wikipedia. Estrogens are important in the sexual development of females.

Can a dog overproduce estrogen?

A dog can overproduce estrogen due to an artificial introduction of hormones or a natural imbalance of hormones. While overproduction of estrogen is more common in female dogs that naturally have higher estrogen levels, overproduction of estrogen may also occur in male dogs.

What is estrogen toxicity in dogs?

Estrogen — a type of hormone — is naturally produced in female dogs. It is responsible for normal sexual behavior and development, and the customary biological function of the female reproductive tract. Overproduction of estrogen can result in what is known as estrogen toxicity (hyperestrogenism).

Do female dog hormones work together?

Several female dog hormones work together, and their balance is what your dog’s body tell what to do. If you want to understand the estrus cycle (commonly known as the dog heat cycle) in female dogs, a basic understanding of how those female dog hormones work is necessary. These are estrogen, progesterone, and luteinizing hormone.

What is a female dog hormone?

Progesterone is another of female dog hormones. It is mostly produced by the yellow body corpus luteum. Your dog’s progesterone levels start to climb right after the above mentioned surge of the luteinizing hormone. Progesterone makes the lining of the uterus receptive for implantation and helps maintain the pregnancy.

Do female dogs produce estrogen?

After being spayed or neutered, dogs lack sex-related hormones (like testosterone and estrogen) that are normally produced by the testicles and ovaries.

What can I put on my female dog for her period?

To manage a dog’s heat cycle (period), use specialized dog diapers or “heat pants” to contain blood and prevent messes, either disposable or reusable, which can be lined with human pads for extra absorbency. Also, ensure your dog is kept on a leash during walks, especially in public, to prevent unwanted attention from male dogs and to avoid accidental mating. Provide your dog with a comfortable, quiet space and offer extra cuddles, but always consult your vet if you notice signs of excessive pain or discomfort.

Do dogs need estrogen after spay?

When a dog or cat gets spayed, thereby removing their uterus and ovaries, they do not have to have hormone replacement therapy.

Do female animals have estrogen?

Yes, female animals have estrogen, as do males, though at different levels and with different primary functions. Estrogen is a naturally occurring steroid hormone essential for the normal development, growth, and reproduction of all vertebrates, including mammals, birds, fish, and reptiles.