Does CBD Really Make Dogs Calm? The Science Behind CBD for Canine Anxiety

September 24, 2025 |

Are you tirelessly searching for ways to help your anxious furball? I’ve been there too watching my Greyhound shake like a leaf during thunderstorms. Many pet parents are turning to CBD as a potential solution for their dog’s anxiety. But does CBD actually make dogs calm? Let’s dive into what the science says, share some real experiences and help you decide if CBD might be right for your nervous pooch.

What Exactly is CBD and How Does It Work for Dogs?

CBD (cannabidiol) is a natural compound extracted from hemp plants. Unlike THC (the stuff that gets humans high), CBD contains minimal THC (less than 0.3%) and won’t make your dog loopy or intoxicated.

Here’s how it works in your dog’s body:

  • CBD interacts with your dog’s endocannabinoid system (ECS) – a complex network of receptors throughout their body
  • The ECS helps regulate mood, sleep, appetite, and stress responses
  • CBD binds to CB1 and CB2 receptors in your dog’s brain and body
  • This interaction may influence the production of neurotransmitters and hormones that regulate mood

As Dr. Joseph Wakshlag from Cornell University explains, “CBD seems to have a place in the treatment of certain conditions in dogs, including anxiety in some cases.”

Real Success Stories: When CBD Helped Anxious Dogs

Some pretty amazing success stories exist. The AKC shares the story of Lady Amelthia, a Greyhound who was absolutely terrified of thunderstorms. Her anxiety was so severe that:

  • She would destroy crates trying to escape
  • Holding her only made her panic more
  • ThunderShirts only reduced her anxiety from “100 to 90” on the scale
  • Veterinary-prescribed trazodone brought it down to “50”

When her owner tried CBD oil, Lady Amelthia’s anxiety plummeted to just a “5” on the scale. That’s a huge improvement!

In a Cornell University study, 83% of dogs given CBD chews before stressful events showed decreased anxiety-related behaviors. That’s promising, right?

Why CBD Might Not Calm Your Dog

But here’s the thing – CBD isn’t a miracle cure for every anxious dog. According to research from the University of Kentucky, CBD wasn’t significantly better than placebo for noise anxiety, and actually performed worse than trazodone in some measures.

So why doesn’t CBD work for all dogs? Several reasons:

1. Individual Differences in Dogs

Just like people, dogs can respond differently to CBD based on:

  • Their unique endocannabinoid system
  • Genetic factors
  • Age and size
  • Underlying health conditions

2. Dosage and Administration Issues

Getting the right dose is tricky:

  • Too little CBD might not have any effect
  • Too much CBD can sometimes create a biphasic response (where it stops working)
  • The timing matters – CBD may need to be given 30-60 minutes before anxiety triggers
  • Some CBD products are best absorbed with food, others on an empty stomach

3. Quality and Purity Problems

Not all CBD products are created equal:

  • A Cornell study of 29 CBD pet products found only 10 contained what they claimed on the label
  • Four products contained heavy metal contamination
  • Two products had no cannabinoids at all!

How to Choose the Right CBD Product for Your Anxious Dog

If you’re considering trying CBD for your dog’s anxiety, here’s what to look for:

Quality Matters

  • Look for products with the National Animal Supplement Council (NASC) Seal of Quality Assurance
  • Choose products with third-party certificates of analysis
  • Avoid human CBD products which may contain ingredients toxic to dogs (like xylitol)

Full-Spectrum vs. Isolate

  • Full-spectrum products contain other beneficial cannabinoids and terpenes
  • CBD seems to work better when combined with these other compounds (called the “entourage effect”)
  • But avoid products with more than 0.3% THC

Dosage Guidelines

Start with about 0.1 to 0.2 mg per kilogram of your dog’s weight, given twice daily. For example:

Dog Weight Starting Dose (twice daily)
10 lbs 0.5-1 mg
25 lbs 1-2.5 mg
50 lbs 2-5 mg
75+ lbs 3-7.5 mg

Remember to start low and gradually increase if needed. And always consult your vet before starting CBD, especially if your dog takes other medications.

Potential Side Effects of CBD in Dogs

While CBD is generally considered safe, some dogs may experience:

  • Drowsiness or lethargy
  • Dry mouth (increased thirst)
  • Changes in appetite
  • Temporary drops in blood pressure
  • Diarrhea (usually with high doses)

More concerning is that CBD can affect liver enzymes, specifically cytochrome P450 and alkaline phosphatase. This is important because these enzymes help metabolize many medications. Using CBD could potentially:

  • Cause other medications to build up to toxic levels
  • Reduce the effectiveness of some medications
  • Interfere with prescription anti-seizure drugs

Beyond CBD: A Comprehensive Approach to Canine Anxiety

We’ve found that CBD works best as part of a comprehensive approach to anxiety. Consider combining it with:

Behavior Modification

  • Desensitization training for specific triggers
  • Counter-conditioning to create positive associations
  • Regular exercise and mental stimulation

Environmental Management

  • Creating safe spaces in your home
  • Using white noise machines during storms
  • Maintaining consistent routines

Veterinary Support

  • Prescription anti-anxiety medications when needed
  • Checking for underlying medical conditions
  • Regular health monitoring

Our Experience Using CBD for Dog Anxiety

I’ve tried CBD with my own anxious rescue dog, and our experience was mixed. For mild anxieties like car rides, the CBD oil seemed to take the edge off. However, for severe thunderstorm phobia, it wasn’t enough on its own – we needed to combine it with other strategies.

What we’ve learned is that patience and consistency are key. It took about two weeks of regular use before we noticed sustainable improvements, and finding the right dose took some trial and error.

The Bottom Line: Does CBD Make Dogs Calm?

The honest answer is: sometimes, for some dogs, in some situations.

CBD shows promise for helping with canine anxiety, but:

  • It’s not a guaranteed fix for every anxious dog
  • Quality and proper dosing are crucial
  • It works best as part of a comprehensive treatment plan
  • Always consult your veterinarian before starting

The research is still evolving, and while some studies show positive results, others have been less conclusive. What seems clear is that CBD may help reduce anxiety in many dogs, but individual results vary significantly.

Talk to Your Vet Before Starting CBD

Most vets are now open to discussing CBD options, even if they can’t officially “prescribe” it. They can help you:

  • Determine if CBD might help your specific dog
  • Check for potential interactions with medications
  • Recommend reputable products
  • Monitor your dog’s response

CBD isn’t a miracle cure, but for some anxious dogs, it might just be the natural support they need to feel calmer and more balanced. With proper research, quality products, and veterinary guidance, CBD could be worth exploring for your anxious furry friend.

Have you tried CBD for your dog’s anxiety? We’d love to hear about your experiences in the comments!

does cbd make dogs calm

When it comes to CBD, it’s important to separate the facts from the fiction.

CBD stands for cannabidiol, which is an oil extracted from hemp plants. Hemp does not contain a significant amount of THC (tetrahydrocannabinol), which is the psychoactive component in marijuana. Hemp itself usually has no more than 0.3% THC. (Cannabis, which is the marijuana plant, contains 12% THC).

For this reason, CBD oil is now approved in most states. Most of the hemp plant is used for other purposes such as making fabric and paper.

Dr. Joseph J. Wakshlag, section chief and professor of clinical nutrition, says veterinarians can now recommend and discuss CBD oil with all clients.

Before Giving CBD to Your Pets: Know This

FAQ

Can CBD help dogs with anxiety?

This is where CBD for dogs with anxiety may come in. Since CBD interacts with the body’s stress-regulating system, it may help ease nervousness, promote relaxation, and reduce anxious behaviors. How Does CBD Help Dogs with Anxiety?

Can CBD help a dog sleep better?

Helping with better sleep – Anxious dogs often have trouble settling down, and CBD may help them rest more easily. While every dog is different, many pet parents report seeing a difference within 30 to 60 minutes after giving CBD. CBD comes in a few different forms, and the best option depends on what your dog likes:

Are FOCL CBD drops good for dogs?

And FOCL’s specially formulated CBD drops for pets top our list when it comes to helping support calm and comfort for anxious dogs. Made according to the highest quality control guidelines, FOCL Premium CBD Pet Drops are available in concentrations of 300 mg or 600 mg strength.

Is CBD good for dogs?

Lead investigator Joe Wakshlag, DVM, Ph.D., DACVN, said that some dogs were initially so decrepit that their owners considered euthanasia, but that after just days on CBD they were trotting around and even climbing stairs. A Baylor University study found similar improvement, adding that CBD worked better when delivered in a liposomal formulation.

How long does CBD take to work for dogs?

While every dog is different, many pet parents report seeing a difference within 30 to 60 minutes after giving CBD. CBD comes in a few different forms, and the best option depends on what your dog likes: CBD Oil – One of the fastest-acting options. Just drop it onto your dog’s food or directly into their mouth.

Does CBD get a dog high?

CBD (short for cannabidiol) is a compound found in hemp plants. Unlike THC, it won’t get your dog high. Instead, it works with your dog’s endocannabinoid system, which helps regulate things like mood, stress, and sleep. CBD comes in different forms, like oils, treats, and chews, making it easy to find an option that works for your pup.

Does CBD actually relax dogs?

In a Cornell study, dogs were given CBD chews prior to a stressful event, and 83% showed a decrease in stress or anxiety-related behaviors.

How long does it take for CBD to relax a dog?

If your dog is given a proper dose of CBD oil, you should notice a more calm, relaxed demeanor within 30 minutes or an hour.Oct 25, 2024

Do vets approve of CBD for dogs?

While many veterinarians support and advise on the use of CBD for dogs due to its potential to help with pain, anxiety, and seizures, they often cannot legally prescribe or recommend it directly due to federal regulations.

Can I give my dog CBD every night?

Yes, you can give your dog CBD every night, and it may be beneficial for their well-being by promoting relaxation and calmness.